Pediatric RISK Stratification Study

Primary goal-

Develop a risk model to predict the prognosis and response to therapy of newly diagnosed patients with Crohn’s disease based on their genetic, immunologic, microbial and clinical profiles

Enrollment is completed. 1794 pediatric patients enrolled from 29 centers across US and Canada.

  • 1,193 with confirmed Crohn’s disease
  • 161 with ulcerative colitis
  • 128 with IBDU -- not classified as Crohn's or colitis
  • 393 with non-IBD

Key findings of the group thus far:

  • 17 genes are expressed differently in intestines of patients who developed a stricture. The group is developing a model for the expression of these genes to be used as predictors of risk for stricture development
  • Children diagnosed under 10 years of age have distinct blood profile antibodies in their blood. These results suggest that there are distinct mechanisms of CD in patients < 10 years