Current Research Studies

The Crohn’s & Colitis Foundation of America supports several major ongoing research initiatives and clinical studies to encourage cooperative efforts among investigators, research centers, and other resources.

Explore the initiatives below to learn more about the broad range of IBD research studies supported by CCFA and how you can become more involved in this important work.

Microbiome Initiative

CCFA partnered with the Center for Genome Sciences at Washington University to develop greater understanding of the role of gut microbes (bacteria, viruses, etc. that are found normally in the intestines) in digestive health and inflammatory bowel diseases. Using the latest generation of massively parallel DNA sequencers and sophisticated computational methods, the initiative studies the complex role that intestinal microbial communities play in digestive health and disease.

Learn more about the Microbiome Initiative.

Genetics Initiative

The Genetics Initiative continues the work of several recent studies that have demonstrated how specific organisms in the gut can cause inflammatory bowel diseases in the presence of specific genes, and that specific genes only cause disease in the presence of specific organisms. The Genetics Initiative is a collaborative effort to better understand the genes and their functions, and the chain of biological events that result in IBD (the pathogenesis of inflammatory bowel diseases).

Learn more about the Genetics Initiative.

Pediatric RISK Stratification Study

The Pediatric RISK Stratification Study is working to “crack the code” of disease prognosis by identifying measurable risk factors for the complications of severe disease. CCFA’s Professional KIIDS Pediatric Network is committed to identifying the genetic, microbiological, and immunological factors that are predictive of more severe disease. The resulting knowledge will translate into new protocols for individualized approaches to treating inflammatory bowel diseases in children and the prevention of severe disease and itslifelong consequences.

Learn more about the Pediatric RISK Stratification Study.

CCFA Partners

CCFA Partners is a comprehensive Internet-based registry designed to study thousands of patients with Crohn's disease or ulcerative colitis under a single research initiative.Unlike prior research, which has typically been conducted in small studies at major medical centers, CCFA Partners tracks the individual experience of more than 14,000 patients diagnosed with inflammatory bowel diseasesthrough three- and six-month reporting updates conducted online.

Learn more about CCFA Partners.

CCFA Clinical Research Alliance

The Clinical Research Alliance is a network of major medical centers and smaller, local facilities collaborating on clinical studies of the management and treatment of IBD.  Members include hospitals, medical centers, clinics, and research facilities that have developed an IBD-related research program administered by a principal investigator.

Learn more about the CCFA Clinical Research Alliance.

Ocean State Crohn’s & Colitis Area Registry

The Ocean State Crohn’s & Colitis Area Registry (OSCCAR) is a collaborative effort of Massachusetts General Hospital and Rhode Island Hospital. In Rhode Island, a small yet diverse population provides an excellent opportunity for demographic-based studies of inflammatory bowel diseases.

Learn more about the Ocean State Crohn’s & Colitis Area Registry.

How to Help

How patients can support Crohn’s & colitis research

How professionals can support Crohn’s & colitis research

Voices of Progress

This colloquium brought together leading researchers to share their latest work in therapies, genetics, nutrition, and much more.

Watch the videos for a glimpse of the future of IBD research.