Challenges in IBD Research
Challenges in IBD Research is a white paper (first published by the Crohn's & Colitis Foundation of America (CCFA) in 1990) that discusses powerful new technologies that may eventually better define the molecular and genetic basis of complex diseases like Crohn's disease and ulcerative colitis.
Below is an excerpt of the Executive Summary:
“Substantial progress has been made since the first “Challenges in IBD Research” white paper was drafted in 1990. Advances in basic science—particularly in immunology, genetics, epithelial cell biology, signal transduction, molecular biology, and other areas—have added greatly to our understanding of disease pathogenesis and have identified many new targets for therapeutic intervention. One important realization that has emerged in the past few years is that a complex and active communication among the bacterial flora, epithelium, and immune cells exists in the intestine and that perturbation of these interactions can result in chronic intestinal inflammation. Thus, the major working hypothesis, particularly coming from basic research in experimental models, is that inflammatory bowel disease (IBD) is due to an abnormal cell-mediated immune reaction…”